Of 119 full-term pregnant subjects studied from October, 1995 to March, 1996, 79 had preeclampsia(severe ; 43, mild ; 36) and 40 were normotensive controls. The plasma fibronectin levels of each subject were assayed by turbidometric
immunoassy(Boehringer Mannheim).
The objective of this study was to evaluate the relationship of plasma fibronectin with preeclampsia as a marker for vascular injury.
@ES The results were as follows :
@EN 1. There were significant differences of plasma fibronectin values among the normotensive pregancy, mild preeclampsia and severe preeclampsia. Within each group of patients, plasm a fibronectin values were 101.7±59.4㎍/ml, 249.7±96.3㎍/ml
and
329.2±169.5㎍/ml, respectively(p<0.001).
2. Plasma fibronectin values had positive correlations with severity of preeclampsia, proteinuria, diastolic blood pressure and systolic blood pressure, but negative correlations with birth weight and platelet count(p<0.001).
3. When the severity of proteinuria on preeclampsia were +1, +2, and +3 or more, plasma fibr onectin values revealed 246.0±93.3㎍/ml, 342.3±185.1㎍/ml and 345.0±168.1㎍/ml, respectively and there were significant differences among three
groups.
4. To verify the variables correlated with plasma fibronectin by using mutiple regression analysis, the only variable which was selected significantly was the severity of preeclampsia(r2 : 0.529).
5. With receiver operating characteristic(ROC) curve analysis of the relationship between plasma fibronectin values and preeclampsia, if cut off value was selected at the level of 175㎍/ml or more, the sensitivity for diagnosis of preeclampsia
was
87.3%, specificity 90.0%, positive predictive value 94.5%, and negative predictive value 78.3%, respectively.
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